After a disappointing draw in the first leg of this tie, David Moyes will be hoping his side can put in a better performance in the Ukraine as the Toffees try to get past the minnows.
Everton travel to Eastern Europe with doubts over the fitness of Andrew Johnson and Leon Osman who both have groin problems. Nuno Valente may also miss the game with a foot injury and Thomas Gravesen (knee) is definitely out.
Although very little is still know of Metalist, Moyes knows that they will continue to pose a threat and only a victory will be good enough to see Everton progress. He will be boosted by the return of Mikel Arteta to European action and Tim Howard is also likely to replace Stefan Wessels in goal.
Metalist will be with Seweryn Gancarczyk and Oleksandr Babych after their red cards at Goodison Park a fortnight ago. Boss Milan Obradovic remains tight-lipped about his starting line-up but hinted that Oleksandr Goryainov would replace Andriy Tlumak in goal as his side try to stop Everton at the back and also hit them on the break.